Poster Presentation 50th Lorne Proteins Conference 2025

Insights into the SH2 domain involved in JAK/STAT/SOCS cascade (#207)

Yuntong Wu 1 , Jason Brouwer 1 , Nadia Kershaw 1 , Jeff Babon 1
  1. Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
Publish consent withheld
  1. Murphy, J. M., J. J. Babon, N. A. Nicola and S. E. Nicholson (2016). The JAK–STAT–SOCS Signaling Cascade. Encyclopedia of Cell Biology: 136-152.
  2. Ferrao, R. and P. J. Lupardus (2017). "The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions." Front Endocrinol (Lausanne) 8: 71.
  3. Lim, C. P. and X. Cao (2006). "Structure, function, and regulation of STAT proteins." Mol Biosyst 2(11): 536-550
  4. Kershaw, N. J., J. M. Murphy, N. P. Liau, L. N. Varghese, A. Laktyushin, E. L. Whitlock, I. S. Lucet, N. A. Nicola and J. J. Babon (2013). "SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition." Nat Struct Mol Biol 20(4): 469-476
  5. Liau, N. P. D., A. Laktyushin, I. S. Lucet, J. M. Murphy, S. Yao, E. Whitlock, K. Callaghan, N. A. Nicola, N. J. Kershaw and J. J. Babon (2018). "The molecular basis of JAK/STAT inhibition by SOCS1." Nat Commun 9(1): 1558.