Tuesday, 11th February 50th Lorne Proteins Conference 2025

• Protein misfolding, pathogenic mechanism, and therapeutic potential for TDP-43 and dipeptide repeats in the neurodegenerative diseases - Yun-Ru Chen
• Phage anti-CRISPR control by a DNA- and RNA-binding helix–turn–helix protein - Nils Birkholz
• An archaic HLA class I receptor allele diversifies natural-killer-cell-driven immunity in First Nations peoples of Oceania - Camilla Faoro
• Structural basis of proteasomal recognition of a branched ubiquitin chain - Shang-Te Danny Hsu

• Cryo-EM structures reveal the molecular mechanism of a co-transcriptional histone modification - James L Walshe
• Mechanistic insights into viral protein function and inhibition using single-molecule FRET  - Nicole C Robb
• Structure, dynamics and evolution of the Candida albicans multi-drug resistance ABC transporter CDR1 - Alice (Jeeeun) Shin
• Amino Acid Sensation and Transport by SLC38A9 - Xuelang (Maymay) Mu
• How Cryo-EM Structures Reveal Molecular Mechanisms of Biomolecular Complexes - Gökhan Tolun
• Engineering carbon-fixing protein cages - Taylor N Szyszka
• The purely thermodynamic anti-prionic mode of action for the treatment of neurodegenerative diseases. - Dieter Willbold
• Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM - Mengqi Pan

• New structure of full-length MLKL reveals novel interface for interdomain communication - Katherine Davies
• Structural insights into the force-transducing mechanism of a motor-stator complex important for bacterial outer membrane lipid homeostasis - Shu-Sin Chng
• Droplet-on-hydrogel bilayer based assay for functional study of membrane proteins - Zuzana Coculova
• Diverse mechanisms of pore-forming proteins as pest controls - Bradley Spicer
• Structural Insights into SLC4 Transporters: Mechanisms of Activity Regulation and Substrate Transport - Yan Jiang
• A few charged residues in galectin-3’s folded and disordered regions regulate phase separation - Jie-rong Huang

•   Characterisation of the replication and maturation processes of Klebsiella targeting phages - Dillon Spark
• Reflex tears and alpha-synuclein: towards a non-invasive biomarker source for Parkinson's disease - Jemima Ganderton
• Establishing a high-throughput drug screening pipeline to target peroxiredoxin decamers - Sydney Austad
• Improving RFdiffusion’s efficacy and performance via data augmentation from the wet lab  - Dylan S Silke
• Enzyme-mediated drug-drug interaction prediction using an atom-bond attention graph transformer with contrastive learning - Yaojia Chen
• Haplotypes and Human Diversity in Proteomics - Jakub Vasicek
• DDMuffin: Transfer learning across molecular graphs for predicting effects of mutations on protein-ligand affinities - Yunzhuo Zhou
• How do chromatin readers modulate the activity of chromatin remodellers? - Clement Luong
• Development and Optimisation of IMPDH Inhibitors in Haemophilus influenzae - Eliza Rowan
• Safer, environmentally friendly pesticides targeting cattle tick hormone receptor - Jen Suh
• Structure-guided discovery of EphB6 modulators to potentiate tumor suppressor functions - Jean-Max Mazeri
• Exploring the Dark Spots in Protein Data Bank - Junjie Xu
• RFDiffusion and High-Throughput Plate-Based Screening Enable Rapid Development of CHD4 Inhibitors - Ivan Jansen
• Advanced Computational Pipeline for Antibody Humanization: Balancing Humanness and Functionality - Georgii Mamistvalov
• Characterization of hTERT Missense Mutations via Machine Learning - Georgina Parra
• A structural perspective on pore formation and regulation of Bacteroides fragilis toxins - Riya Joseph
• Identification of catalytic residues using an alignment-free approach based on enzyme structural context - Tong Pan
• The mechanisms underlying nucleosome binding by the BET proteins and their role in regulation of ATP-dependent chromatin remodelling. - Lucien Lambrechts
• SGGly: Structure-Guided N-Linked Glycosylation Prediction Using a Pretrained Large Language Model and Deep Neural Networks - Xiaotong Gu
• Predicting Protein Stability from Mutations: Quantum SVM vs. Classical Models - Vladimir Morozov
• Life or Death: Competing functional amyloid fibrils in the programmed cell death pathway necroptosis - Brayden Williams
• The regulation of the undruggable enzymes in a critical metabolic junction in the persistent Mycobacterium tuberculosis - Evelyn Y.W. Huang
• Ethylene-forming enzyme: a redox-regulated switch in ethylene biosynthesis - Francis Kuang
• Characterization of Cell-Cell Interaction Mechanisms in Novel Archaea - Milad Reyhani
• A Novel Inhibitory Role For A Muscle-specific AMPKγ3: A Therapeutic Target for Type 2 Diabetes Mellitus - Muhammad Nur Hamizan Bin Khabib
• Rational Design and Production of SARS-CoV-2 Multi-Epitope Proteins: An Approach for Immunotherapeutic Production - Mayara T. L. Silva
• Investigating the conformation of apoptotic pores using expansion microscopy - Bochen Zhu
• Targeting Y374-PKCδ Phosphorylation in Triple Negative Breast Cancer for Overcoming Chemoresistance - Mia Mulheron
• Structural and biochemical analysis of the Bloom Syndrome complex - Shraddha Kameshwar
• NAD⁺ NUCLEOSIDASE ACTIVITY AND STRUCTURAL STUDY OF BACTERIAL TIR-DOMAIN CONTAINING PROTEIN PUMA - Chen Yang Lai
• Deep Mutational Scanning of SARS-CoV-2 Proteases. - Xinyu Wu
• SAResNet: self-attention residual network for predicting DNA-protein binding - Long-Chen Shen
• Mapping the ‘CRECome’: an understudied class of calcium sensor proteins - Lucy J Mather
• Deciphering the essential complexity of mitochondrial Signal Transducer and Activator of Transcription 3 (STAT3) biology - Sibo NY Yu
• Investigating the role of glutamine transporters in uptake of biologically inert platinum-compounds for targeting cancer cells - Bronte Carroll
• Use RoseTTAFold diffusion as a next-generation protein design strategy - Lihua Yang
• THE DESIGN OF CHD4-BINDING PROTEINS FOR THE TREATMENT OF HEMOGLOBINOPATHIES   - Sebastian Abby Pratama
• Exploring uncharacterised flagellar proteins in the S-layer containing Gram-positive bacterium, Bacillus solimangrovi - Isa Nuryana
• Functional characterization of ataxia-linked mutations in a human glutamate transporter - Emily Zhou
• Enhancing the plasma half-life of broad-spectrum chemokine binding tick proteins by fusion to XTEN tags - Mikaela Bell
• Developing a Pipeline for Combinatorial Engineering of Tick Evasins - Levi Naunton
• The Vpb Proteins: Diverging Molecular Mechanisms of an Insecticidal Bacterial Exotoxin B Group. - Raymond Wirawan
• Exploring Protein Fibrils from Self-Assembly to Drug Delivery: Mechanistic aspects - Anu Jain
• The development of novel ecofriendly selective pesticides for the maintenance of managed honeybees - Zahra Falahati
• Interrogating the N-terminal domain of TDP-43 for ligand discovery - Nicholas M McAndrew
• Investigating the structural basis for the interaction between the chromatin remodeler CHD4 and the BET-bromodomain proteins. - Andrea Daners
• Characterisation of a novel C. elegans glutamate transporter homologue - Alice McCann
• Structural illumination of substrate binding, mechanism, and membrane interface of recluse spider phospholipase D toxins - Alexandra K Sundman
• Exploring the Stability of the Plakin-Repeat Domain of Plectin. - Laura J Walsham
• To Find a Phosphoprotein: Identifying a Key Protein in a Novel Marine Paramyxovirus - Daniel Body
• Characterisation of CD4/8+ T Cells in Peripheral Blood Mononuclear Cells Isolated from Human Immunodeficiency Virus-Infected Humans  - Jamie Tuibeo
• OCT4 in Colorectal Cancer Stem Cells: Implications for Therapeutic Targeting - Reem ALHulais
• Structure-Function Analysis and Engineering of Tick Anti-inflammatory Proteins - Surendra Kunwar
• Investigating the structure of TolC-like proteins in Gram positive bacteria - Sneha Desa
• Restoring the Sensitivity of Pseudomonas aeruginosa to Polymyxin Using Bacteriophage vB3530 - Huanchang Chen
• Defining the structural basis of allosteric activation of CaMKK2 by fatty acid metabolites and the scaffolding protein IQGAP1. - Abbey G Muller
• A journey to cell death: amyloid-fibril formation of initiator caspases drives necroptosis - Abigail J Schwartfeger
• Novel dimerisation domain discovered may regulate gene regulatory function of PWWP2A -
• Defining the biological interactions of the transcriptional regulator HiNanR - Ashleigh S. Johns
• Unravelling the Role of ENOD93 in Cytochrome c Oxidase Regulation and Hypoxia Tolerance in Plants - Selin Altintas
• [NiFe]-hydrogenases in Asgard archaea resemble Complex I - James Lingford

History of Lorne Conference on Protein Structure and Function

Speakers:

1976-1985 Lindsay Sparrow, Growth Factors and protein sequencing and separation

1986-1995 Marilyn Anderson, Glycoproteins and emerging protein engineering and design

1996-2005 Robin Anders, Protein misfolding and disease

2006-2015 Jacqui Matthews, The Study of Structure and Protein Interactions

2016-2025 James Whisstock, Advanced Techniques and Multidisciplinary Research

• Nanobody therapeutics against human coronaviruses - Phillip Pymm
• Using machine learning and enhanced sampling to expand the toolbox in structure-based drug discovery - Albert Ardevol
• Developing new-to nature de-novo design CRISPR-Cas13 inhibitor  - Nathan NC Chai
• A structural insight into ligand recognition by the Thrombopoietin Receptor (TpoR) - Lilian Wong
• Structural insights into MSP2 and AMA1, two structurally diverse merozoite vaccine candidates  of Plasmodium falciparum - Mick Foley
• Expanding the toolbox for targeted protein degradation - Michael J Roy
• A Gene Circuit Enabling Directed Evolution of Genome-Free Protein Cages - Rezwan Siddiquee
• Development of an enrichment technique for AMPylation - Abner J Gonzalez Castro
• LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR - Christopher J Lupton
• Characterisation DPANN symbiosis by electron cryo-tomography - Matthew D Johnson
• Genetic variation in individuals from a population of the minimalist bacteriophage Merri-merri-uth nyilam marra-natj driving evolution of the virus - Kher Shing Tan
• Study on the structure-activity relationship of dual-specificity phosphatase 22 mutants in patients with systemic lupus erythematosus - Ping-Chiang Lyu
• Single particle cryo-EM analysis of spirochete periplasmic flagella - Luca Troman
• A pair of pliers, a blowtorch and a hacksaw: mTORC1 and caspase-3 get to work on AMPK - Ashley J. Ovens
• Shared and distinct sequence-function signatures define different modes of TpoR activation - Matthew E Call
• Insights into a novel DNA-binding domain in SMCHD1 - Alexandra Gurzau
• Structural and functional characterisation of the flax L6 innate immune receptor - Dalton H. Y. Ngu
• LDB Proteins – from homodimers to tetramers to selective heteromerisation - Jacqui Matthews
• Visualising structural biology data of Class B1 GPCRs in 3D animations - Sarah Piper
• Structural Characterisation and Comparison of Temperature and Pressure Stress on a Protein Library Across pH and Concentration Using Microfluidic Modulation Spectroscopy - Peter Davis
• Simulations of TamB suggests it facilitates lipid transport from the bacterial inner membrane  - Yie Chang Lin
• Probing allosteric activation and biased signaling with rigidity transmission allostery (RTA) theory, NMR, and geometric Monte-Carlo simulations - Adnan Sljoka
• PSKH1 kinase activity is differentially modulated via allosteric binding of Ca²⁺ sensor proteins - Chris R Horne
• Quantitative Calorimetric and Spectroscopic Analysis of Solid Lipid Nanoparticles with protein - Jyoti Jyoti
• Structural Characterization and Comparison of Temperature and Pressure Stress on a Protein Library Across pH and Concentration Using Microfluidic Modulation Spectroscopy - Peter Davis
• Computational design of potent and selective binders of BAK and BAX - Richard W Birkinshaw
• BigMAC – Simplifying mammalian expression of multi-component systems. - Charles Bayly-Jones
• Protein Production, characterisation​ and X-ray crystallography at Sydney Analytical (USYD). - Chandrika Deshpande
• Elucidating the structural dynamics of the nickel transporter Ynt and its implications for urease activity in Proteus mirabilis - Sarah L. Mueller
• Using alpaca hyperimmunisation as a strategy to improve affinity and breadth of nanobodies against SARS-CoV2 variants - Lynn Tan
• STRUCTURAL BASIS FOR ETHER-BRIDGE FORMATION BY DIVERGENT ALPHA-KETOGLUTARATE-DEPENDENT NON-HEME IRON ENZYMES INVOLVED IN ANTIBIOTIC BIOSYNTHESIS.   - Shadi Maghool
• Towards the Structure of Amyloid Fibrils formed by the Human Glucagon-Like-Peptide 1 (hGLP-1) - Aidan B Grosas
• Sample preparation and characterization: modular access to structural studies at the European XFEL - Ekaterina Round