Monday, 10th February 50th Lorne Proteins Conference 2025

• What do we know about (your) antibodies?: Novel insights from mass spectrometry - Albert Heck
• Deciphering Dysregulated Molecular Pathways in Huntington's Disease: The Role of HTT in DNA Mismatch Repair - Christian Makhoul
• FUT10 and FUT11 are novel protein O-fucosyltransferases that modify protein EMI domains - Mark Larance
• Mechanisms of Pyruvate Kinase Allosteric Regulation by CryoEM and HDX-MS - Sheena D'Arcy Ph.D.

• Insecticidal proteins from ferns resemble Bacillus thuringiensis toxins - Megan J Maher
• LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR - Andrew Ellisdon
• USING CRYO-ELECTRON MICROSCOPY TO UNDERSTAND THE BIOLOGY AND DRUG BINDING OF THE WNT SIGNALLING PATHWAY - Alisa Glukhova
• A PPR protein-based FRET sensor for RNA - Charles S Bond

Please make your way to the putting green near the Mantra Restaurant as soon as the session finishes. 

• High-affinity PQQ import is widespread in gram-negative bacteria - Fabian Munder
• A universal rapid test for protein-nucleic acid interactions - Casey Toft
• Deciphering the essential complexity of mitochondrial Signal Transducer and Activator of Transcription 3 (STAT3) biology - Nelson / Sibo NY Yu
• Exploiting cancers metabolism: A structural focus on malic enzyme inhibitor NPD-389 using structural-based drug design. - Ben Krinkel
• Immunogenic HLA-B*44:03 restricted peptide does not induce the same response in individuals with B*44 superfamily molecules   - Samuel Liwei Leong
• Structural characterisation of the interactions between the SIN3 PAH domains and their binding partners - Bhagya Mendis
• A molecular twist: Unveiling formate binding in a predicted amino acid binding protein in marine picocyanobacteria. - Anushka Vidurangi Samaraweera
• When Necroptosis meets Protein Liquid-liquid Phase Separation - Tianchen Li
• Flexible and contractile Herelleviridae bacteriophage JS1 showing cross-species activity against Staphylococci - Sabrina Suhani
• PmxPred: A data-driven approach for the identification of active polymyxin analogues against gram-negative bacteria - Xiaoyu Wang
• Mechanism of CD8+ T cell cross-reactivity to SARS-CoV-2 and seasonal coronaviruses epitopes - You Min Ahn
• Epitope-anchored contrastive transfer learning for paired CD8⁺ T cell receptor–antigen recognition - Yumeng Zhang
• Understanding the Ubiquitination and Characterisation of the Atypical Kinase RIOK3 - Jacqueline J.L Ormsby
• Harnessing AlphaFold and explainable AI to better characterise human missense variants and diseases - Qisheng Pan
• Towards a selective insecticide against the green peach aphid - Simone Titterton
• A PaRTI at the FunCyDisCo – Expression of Cysteine-Rich Myrtle Rust Effector Proteins in E. coli Using a Coexpression System - Jovarn Sullivan
• Thiolate oxidation of the p18^INK4c tumour suppressor protein induces its transition into amyloid structures. - Emilie M. Hamzah
• Investigation of the interaction between gating modifier toxins and voltage-gated ion channels using cyclised nanodiscs - Yifei Zhu
• Structure and function of the novel endolysin, PA3 - Mackenzie Aitken
• Understanding the molecular structure and signalling functions of Eph receptor pseudokinase EphA10 - Emily C Park
• Uncovering the differential function and expression of DCLK1 isoforms in aggressive cancers - Lyn R. Deng
• Structural and functional characterisation of novel piezo1 mutations causing hydrops fetalis - Zhou Yi Wang
• How does size affect the affinities of peptide ligands discovered via mRNA display? - Xuefei Jing
• Therapeutic targeting of proteins involved in Toll-like receptor signalling - Vishal Pandey
• Can we generate ligands selectively binding integral membrane protein? - Junyu Liu
• Lost in space: Radiation-triggered fibril formation of p16^INK4a aboard the International Space Station - Shelby G Gray
• Cyclic peptides as novel probes to study the RIPK3 RHIM functional amyloid - Jessica Buchanan
• Ultrasonication-Enhanced β2-Microglobulin Amyloid Formation: Effects of Temperature and Salt on Folding and Misfolding - Tomoki Ota
• Determining How Lectin-Like Antibiotics Kill Pseudomonas spp. Using Proteomics and Phenotypic Analysis - Imogen Samuels
• AI-designed protein inhibitors can block heme uptake and inhibit growth of pathogenic E. coli - Daniel R. Fox
• Tailoring tailocins: development of a recombinant expression system for modular phage tail–like bacteriocins - Jose Benjamin P. Dar Juan
• Towards the development of Safer Ecofriendly Selective Pesticides to safeguard honeybees - SHAHNAZ SULTANA
• Novel peptide-based inhibitors of protein kinase Cε interactions for the treatment of type 2 diabetes mellitus - Abisola A Siedoks
• Unveiling the Versatility of the Thioredoxin Framework: Insights from the Structural Examination of Francisella tularensis DsbA1.  - Stephanie Penning
• Integrative Bioinformatic Approach to Identify Gluten-Degrading Proteins in the Gut Microbiome: Uncovering Microbial Enzymes with Therapeutic Potential for Celiac Disease - Peter Prendergast
• Prediction of the toxicity of proteins and peptides by exploiting structural information based on deep learning - Jing J Xu
• Further insights into asymptomatic outcome after SARS-CoV-2 in HLA-B*15:01+ individuals - Lawton Murdolo
• Characterise the COMMD-like Proteins from Bacteria and Archaea - Meihan Liu
• Insights into the mechanism of the Streptococcus pneumoniae glutathione import system - Sarah E du Toit
• Expanding substrate diversity of O-fucosylation through structural alignment and glycoproteomics - Benjamin Eberand
• Expanding the Redox Response: Crosstalk Between Dsb and Scs Systems in Klebsiella pneumoniae - Callum O'Flaherty
•   Investigating the role of the hydrophilic loop in the oligomerisation and activation of VacA - William Elliott
• Monitoring the Oxidation-Induced Amyloid State of Tumour Suppressor Protein p16ᴵᴺᴷ⁴ᵃ in human cell culture - Alex Botha
• Elucidating the mechanism of action of a small molecule endocytosis inhibitor - Philip Zhong
• Respiratory chain coupling proteins: A novel and widespread mechanism for microbial quinone reduction - Ashleigh Kropp
• Identification of Rab GTPase interacting partners using AlphaFold2 - Denaye Eldershaw
• Investigating T cell responses to a nested peptide - Georgia Dow
• EXPLORING PROTEIN INTERACTIONS BETWEEN ENVIRONMENTAL KLEBSIELLA AND THE BACTERIOPHAGES THAT RECOGNIZE THEM - Alex Hall
• A modular vector system for baculovirus expression streamlines the production of large protein complexes - Zhihao Lai
• Decoding PLD3: Structural and functional discoveries with therapeutic potential for Alzheimer’s Disease - Maria Eleni Georgopoulou
• Looking deeper into outer membrane porin loss and resistance to β-lactam drugs including carbapenems in Klebsiella pneumoniae. - Jiahui Li
• Analytical ultracentrifugation: Old dog, new tricks - Zachary D Tillett
• RNA Substrate Recognition by CRISPR-Cas13 HEPN Nucleases - Roland W Calvert
• Structure and function of NanU, an extracellular neuraminate uptake protein in gram-negative bacteria - Ruosong Zhang
• Developing a biosensor to map the interactome of CaMK4: An emerging therapeutic target for profound Autism spectrum disorders - Bethany Lei
• Structural characterization of INPP4B: insights into the final unsolved human phosphoinositide phosphatase family - Gareth D Jones
• Structural and Functional Insights into Substrate Recognition by the Bacterial Virulence Regulator DsbA - Taylor Cunliffe
• Exploiting tau amyloid polymorphism for diagnosis of Chronic Traumatic Encephalopathy (CTE) - Joanna L New
• Breaching the cell wall: How phages enter their DNA through the peptidoglycan layer. - Kishani Naligama

• The Commander Complex: A Comprehensive Analysis. - Michael Healy
• Structural basis of toxin delivery by the Type VI Secretion System. - Brooke K Hayes
• Dissecting GPCR function through nanodiscs; structural and pharmacological approaches - Wessel A C Burger
• Mechanical activation of OSCA channels opens a lipid lined pore - Ruitao Jin

• Molecular mechanisms of lipid antigen presentation to T cells in protective or aberrant immunity - Adam Shahine
• A peptidic molecular glue exploits differences in protein dynamics to drive high paralogue selectivity among BET-family bromodomains - Joel Mackay
• Unconventional Secretion and Activity of SARS-CoV-2 Main Protease (3CLpro) by Caspase and 3CLpro Activation of Gasdermin D Pore Formation - Chris Overall
• Molecular basis for neutralization of the bacterial type I restriction-modification system by a phage protein - Suk-Youl Park
• Reconstitution of ACE2-S1-RBD interaction on supported lipid bilayer reveals endocytosis-mediated Omicron S1-RBD internalization  - Angelin Philip
• Picking up the PACE: Structural characterisation of a novel PACE efflux pump - Bhumika S Shah
• Insights into the SH2 domain involved in JAK/STAT/SOCS cascade - Yuntong Wu
• Silence is Golden: How is quiescence regulated in Klebsiella and what is the significance of quiescent porins in AMR? - Kwok Jian Goh
• MMS EVALUATION OF HOS FOR IGG SAMPLES SPIKED WITH BSA - Peter Davis
• Functional Ambidexterity of an Ancient Nucleic Acid-Binding Domain - Yael Dr Fridmann Sirkis
• The association and molecular mechanism behind asymptomatic SARS-CoV-2 infection - Dimitra SM Chatzileontiadou
• Structural Insights into A Novel Chi-like Phage Targeting Multiple Klebsiella spp. - Yan Li
• A novel conformation-specific BAK antibody enables assessment of non-activated BAK levels in cancer cells - Michelle Miller
• Investigating phosphorylation-dependent interactions between JAKs and PTP1B - Hao Chen
• Investigating complex molecular interactions using novel SPR analysis approaches   - Emma Dal Maso
• TEMPO: Training in Electron Microscopy Processing and Optics - Joshua M Hardy
• How does intra-protein motion influence protein function? Cryptochrome magnetoreception and cryptophyte light-harvesting - Gesa Gruening
• TFold for accurate peptide-HLA structure prediction - Janesha Maddumage
• How is the bacterial flagellar secreted through the Gram-positive S-layer? - Christopher Stubenrauch
• Native mass spectrometry prescreening of G protein-coupled receptor complexes for cryo-EM structure determination - Weijing Liu
• Using minicells to examine the β-barrel protein arrays of Klebsiella pneumoniae - Cara Press
• Measuring interactions between synthetic TM domains in live cell membranes for CAR-T cell immunotherapy development - Colin Hockings
• Mechanical activation of OSCA channels opens a lipid lined pore - Ruitao Jin
• Mechanisms of amyloid fibril formation under ultrasonication using HANABI - Keiichi Yamaguchi
• Now I'm amyloid, now I'm not - A single redox switch controls structure and function of a tumour suppressor protein family - Christoph Goebl
• TRADING TAILS: Identification of native protein scaffolds leading to the engineering of designer bacteriophages. - Rhys Dunstan
• Structural investigation of allosteric modulation of the delta opioid receptor - Jesse I Mobbs
• How similar are protein crystallisation conditions? A Data-Driven Approach Using Deep Metric Learning. - Nicholas Rosa
• Enhancing the stability of the SOCS2 SH2 domain in a ligand-independent manner - Cyrus Tan
• On developing hidden Markov models using a structural alphabet - Ashar Malik
• A structural basis of allosteric ligand selectivity at GPCRs - David M Thal
• Improving the breath and affinity of nanobodies against SARS-CoV-2 Omicron variants - Lynn Tan
• DNA partition modulates the liquid-to-solid transition of FUS protein condensates - Yi Shen

Conference Social Hub
9.00pm - 1.00am
Pholklore - 82 Mountjoy Pde
- Drinks at bar prices
- Will stay open for conference delegates if you continue to drink at the bar.