Poster Presentation 50th Lorne Proteins Conference 2025

Characterisation of CD4/8+ T Cells in Peripheral Blood Mononuclear Cells Isolated from Human Immunodeficiency Virus-Infected Humans  (#354)

Jamie Tuibeo 1 , Anurag Adhikari 1 , Stephanie Gras 1
  1. La Trobe University, Bundoora, Victoria, Australia

Human Immunodeficiency Virus (HIV) is still a highly prevalent virus to this day and infection is well known to lead to development of acquired immunodeficiency syndrome (AIDS). Despite the development of effective therapies, such as antiretroviral therapies (ARTs), that can lower viral load to undetectable and untransmissible levels, the virus cannot be completely eradicated. The development of an HIV vaccine is crucial in prevention and therapeutics, either blocking HIV from infecting or by treating those already infected. Previous vaccine trials, such as the RV 144 trial, have shown the effectiveness of an antibody response in combination with a modest T cell response in conferring some protection to the virus, highlighting the need to study both humoral and cellular responses and characteristics in those living with HIV. In this work we aim to characterise the CD4+ and CD8+ T cell profiles and responses in a HIV-positive cohort living in Nepal, where HIV is epidemic. Included in this cohort is a rare group of individuals termed ‘controllers’ who have the capacity to maintain an undetectable HIV viral load without the use of ARTs. This poster presents preliminary data where we show the absolute counts of CD4+ and CD8+ T cells in both controller and non-controller populations, also showing and comparing patient demographics.